Sharpsburg, Md. Principal Street (U.S. Civil War) Sharpsburg Principal Street, located in the town of Sharpsburg, Maryland, holds historical significance due to its association with the U.S. Civil War, particularly the Battle of Antietam fought nearby on September 17, 1862. The battle was one of the deadliest single-day conflicts in American history and is considered a turning point in the war. Today, the street serves as both a symbol of historical preservation and a bustling commercial area within Sharpsburg. Key sites along Principal Street include the Pry House where President Lincoln stayed after the battle, the National Park Service Visitor Center, and various shops and eateries that cater to tourists seeking to learn more about this significant period in American history.